D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
N-Methyl-D-glucamine
CAS: 6284-40-8
Molecular Formula: C7H17NO5
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- - Names and Identifiers
| Name | N-Methyl-D-glucamine |
| Synonyms | Meglumin Meglumine Methylglucamin Methylglucamine n-methylglucamine N-Methyl-D-glucamine D(-)-N-METHYLGLUCAMINE 1-Deoxy-1-(methylamino)hexitol 1-deoxy-1-(methylamino)hexitol 1-deoxy-1-methylamino-D-glucitol 1-deoxy-1-(methylamino)-d-glucito 1-deoxy-1-(methylammonio)-D-allitol 1-deoxy-1-(methylammonio)-D-glucitol 1-deoxy-1-(methylammonio)-D-altritol D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- 1-deoxy-1-(methylammonio)-D-mannitol Glucitol, 1-deoxy-1-(methylamino)-, D- |
| CAS | 6284-40-8 |
| EINECS | 228-506-9 |
| InChI | InChI=1/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/p+1/t4-,5-,6+,7-/m1/s1 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- - Physico-chemical Properties
| Molecular Formula | C7H17NO5 |
| Molar Mass | 195.21 |
| Density | 1.2669 (rough estimate) |
| Melting Point | 129-131.5 °C (lit.) |
| Boling Point | 331.88°C (rough estimate) |
| Specific Rotation(α) | -16.5 º (c=10, H2O, on dry sub) |
| Flash Point | 251.6°C |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Solubility | Soluble in water, slightly soluble in ethanol, solubility: 100G/100 ML of water (25°C), 1.2G/100 ML of ethanol (25°C),21G/100 ML of ethanol (70°C). Almost insoluble in chloroform, |
| Vapor Presure | 1.12E-11mmHg at 25°C |
| Appearance | White crystal |
| Color | White to almost white |
| Merck | 14,6078 |
| BRN | 385906 |
| pKa | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| PH | 11 (10g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive & Hygroscopic |
| Refractive Index | -16.5 ° (C=2, H2O) |
| MDL | MFCD00004707 |
| Physical and Chemical Properties | Melting point 128-132°C specific optical rotation -16.5 ° (c = 10, H2O, on dry sub) water-soluble 100g/100 mL (25°C) |
| Use | Diagnostic agents, cosolvents for contrast media, surfactants |
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LZ4295770 |
| FLUKA BRAND F CODES | 3-10-23 |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- - Introduction
The taste is slightly sweet and salty.
Last Update：2022-10-16 17:27:25
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | meglumine selecting a suitable balance for the drug is particularly important for improving the solubility and bioavailability of the drug. Meglumine (N-methyl-D-glucosamine, Meglumine) is a balance ion that is widely used to improve the solubility of drugs. It is an amino sugar of sorbitol origin with a pKa value of 9.6. |
| Use | as a cosolvent and surfactant for contrast agents. Diagnostic agents, as cosolvents for contrast agents and Diagnostic agents, cosolvents and surfactants for contrast agents biochemical studies |
| production method | is obtained by condensation of glucose with monomethylamine followed by catalytic hydrogenation. Anhydrous ethanol and dry glucose were added to the reaction pot, and the dry monomethylamine gas was introduced at 50 ℃. After 1.5-2H of reaction, the solution was gradually clarified and kept at 50 ℃ for 2H, A solution of glucose in methylamine was obtained. It was then added to the autoclave and pressurized to 2.5MPa with hydrogen in the presence of rexler's nickel and stirred for 1-2H at 80-85 °c. Then, after cooling and depressurization, the material is discharged, the upper meglumine ethanol solution is cooled and crystallized, filtered to obtain the crude product of meglumine, and then refined to obtain the finished product. |
| autoignition temperature | ~ 662 F |
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: Meglumine；N-methylglucamine Request for quotationCAS: 6284-40-8
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Spot supply
Product Name: N-Methyl-D-glucamine Request for quotationCAS: 6284-40-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: N-Methyl-D-glucamine Request for quotationCAS: 6284-40-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: N-Methyl-D-glucamine Request for quotation
CAS: 6284-40-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 6284-40-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Meglumine Visit Supplier Webpage Request for quotationCAS: 6284-40-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: N-Methyl-D-glucamine Request for quotation
CAS: 6284-40-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 6284-40-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Meglumine Visit Supplier Webpage Request for quotationCAS: 6284-40-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Featured ProductsSpot supply
Product Name: Meglumine；N-methylglucamine Request for quotationCAS: 6284-40-8
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Spot supply
Product Name: N-Methyl-D-glucamine Request for quotationCAS: 6284-40-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: N-Methyl-D-glucamine Request for quotationCAS: 6284-40-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: N-Methyl-D-glucamine Request for quotation
CAS: 6284-40-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 6284-40-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Meglumine Visit Supplier Webpage Request for quotationCAS: 6284-40-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: N-Methyl-D-glucamine Request for quotation
CAS: 6284-40-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 6284-40-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Meglumine Visit Supplier Webpage Request for quotationCAS: 6284-40-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History